Chemistry (CHEM)

CHEM 1135. Engineering Chemistry Laboratory.

This course is a laboratory course that represents a combination of general chemistry I and II techniques designed for engineering and closely related majors. The laboratory course is intended to accompany the CHEM 1335 Engineering Chemistry lecture course. Students enrolled in this laboratory course will learn and practice chemical techniques, including titrations, electroplating, mixture separation, spectrophotometry, and the construction and utilization of calibration curves. The experiments are meant to supplement the topics covered in the lecture course, such as experimental measurements and the study of density, solubility, limiting reagents, gas laws, conductivity, equilibria, thermodynamics, and electrochemistry. Corequisite: CHEM 1335 with a grade of "C" or better.

CHEM 1141. General Chemistry Laboratory I.

This course is the first of two laboratory courses in general chemistry for science majors. The course provides hands-on experimental opportunities for students to explore the practical aspects of topics taught in general chemistry lectures. Students develop foundational laboratory skills, including accurate measurements, solution preparation, volumetric and qualitative analysis, and data collection. Experiments reinforce core chemical principles, such as density, solubility, separation techniques, stoichiometry, acid-base chemistry, thermochemistry, gas laws, and descriptive chemistry, while promoting safe laboratory practices and scientific reasoning. Corequisite: CHEM 1310 or CHEM 1341 either with a grade of "D" or better.

CHEM 1142. General Chemistry Laboratory II.

This course is the second of two laboratory courses in general chemistry and expands students’ technical and instrumental skills through hands-on experimentation. Students develop proficiency in using laboratory equipment, including spectrophotometers, while applying chemical principles to experiments involving acid-base titrations, metathesis reactions, and intermolecular forces. Emphasis is placed on accurate data collection, proper documentation, and scientifically sound interpretation of results. Through guided practice and structured opportunities for independent practice, students strengthen laboratory techniques, deepen their understanding of chemical behavior, and build confidence in executing experimental procedures and analyzing outcomes. Prerequisite: CHEM 1141 and CHEM 1341 both with grades of "C" or better. Corequisite: CHEM 1342 with a grade of "C" or better.

CHEM 1310. Introductory Chemistry for Non-Science Majors.

This course introduces the physical and chemical properties of matter. Topics include atomic structure, the periodic table, chemical bonding, molecular geometry, the states of matter, gas laws, solutions, types of chemical reactions, and stoichiometry. Students will make connections between chemical principles and their daily lives. This course is intended for students in non-science majors. It is not intended as preparation for general chemistry.

CHEM 1320. Foundations of Chemistry.

This course supports student success in CHEM 1335 and CHEM 1341 by providing a foundation in mathematical skills and fundamental chemical concepts. Topics include basic mathematics for chemistry, chemical formulas and equations, quantitative problem solving, and the application of scientific laws to describe the behavior of matter from macroscopic to atomic levels. Students may choose to complete the online Chemistry Readiness Program in place of ALEKS modules and may test out of the course by demonstrating appropriate proficiency. Corequisite: [MATH 1315 or MATH 1317 or MATH 1319 or MATH 1329 or MATH 2321 or MATH 2417 or MATH 2471 any with a grade of "C" or better] or [ACT Mathematics score of 24 or better] or [SAT Mathematics score of 550 or better] or [Accuplacer College Mathematics score of 86 or better] or [Compass College Algebra score of 46 or better] or [Next-Generation Advanced Algebra and Functions Test of 263 or better].

CHEM 1330. Organic and Biochemistry for Non-Science Majors.

This course is the second of two lecture courses for non-science majors. The course surveys the fundamentals of organic chemistry and biochemistry applied to contemporary topics. Course content may encompass energy-related issues, nuclear chemistry, environmental chemistry, and medicinal chemistry, with applications to real-world contexts. Students examine carbon-containing compounds, which eventually leads to the evaluation of chemicals in our daily lives. Additionally, this course covers synthetic and natural chemicals, including macromolecules such as proteins and nucleic acids, as well as their fundamental building blocks: amino acids and nucleotides. Prerequisite: CHEM 1310 or CHEM 1341 either with a grade of "C" or better.

CHEM 1335. Engineering Chemistry.

This course is tailored to engineering students. Topics include stoichiometry, gases, chemical bonding and structure, periodic trends, materials, energy, kinetics, equilibrium, and electrochemistry. A major focus is the application of mathematical principles to solve chemical problems, often through word problems that require careful analysis. Students analyze and apply the language, symbols, and notation of chemistry, as well as the scientific method and examine relationships among chemical principles and their relevance to macroscopic matter behavior.. Prerequisite: [[MATH 1315 or MATH 1317 or MATH 1319 or MATH 1329 or MATH 2321 or MATH 2417 or MATH 2471 any with a grade of "C" or better] or [ACT Mathematics score of 24 or better] or [New ACT Mathematics score of 25 or better] or [SAT Mathematics score of 550 or better] or [Accuplacer College Mathematics score of 86 or better] or [Compass College Algebra score of 46 or better] or [Next-Generation Advanced Algebra and Functions Test of 263 or better]] and [[CHEM 1320 with any grade of "C" or better] or [ALCH00 score of 80 or better]].

CHEM 1341. General Chemistry I.

This course is the first of two lecture courses in general chemistry for science-related majors. It covers atomic and molecular structure, the periodic table, chemical bonding, stoichiometry and chemical reactions, states of matter, thermochemistry, solutions, and gases. A major focus of the course is applying mathematical principles to solve chemical problems, often through word problems. Students analyze and apply the language, symbols, and notation of chemistry, and examine relationships between chemical principles and the macroscopic behavior of matter. Prerequisite: [[MATH 1315 or MATH 1317 or MATH 1319 or MATH 1329 or MATH 2321 or MATH 2417 or MATH 2471 any with a grade of "C" or better] or [ACT Mathematics score of 24 or better] or [New ACT Mathematics score of 25 or better] or [SAT Mathematics score of 550 or better] or [Accuplacer College Mathematics score of 86 or better] or [Compass College Algebra score of 46 or better] or [Next-Generation Advanced Algebra and Functions Test of 263 or better]] and [[CHEM 1320 with any grade of "C" or better] or [ALCH00 score of 80 or better]].

CHEM 1342. General Chemistry II.

This course builds on the topics covered in the first general chemistry course for science-related majors. Students examine concepts such as the effects of molecular structure on molecular behavior, including intermolecular forces; solution chemistry, including solubility; the effects of reaction parameters on reaction rates; nuclear chemistry; the extent of reactions; acid-base theory; chemical disorder and spontaneity; and the relationship between chemical reactions and electrical energy. Students apply mathematical reasoning and critical thinking to analyze relationships among variables, predict the effects of parameter changes, and connect scientific concepts to real-life applications. Prerequisite: CHEM 1341 with a grade of “C” or better.

CHEM 2130. Laboratory Techniques in Organic Chemistry.

This course supports the learning outcomes of CHEM 2330 by providing hands-on experience with experimental techniques of preparation, purification, and determination of physical and chemical properties of organic compounds. In this course, students will isolate a component of a drug mixture using recrystallization and identify the unknown substance using melting point data. Students will use qualitative data to identify the presence of functional groups, investigate the relative acidity of compounds, and synthesize a set of esters from carboxylic acids and alcohols. Students will also observe SN1 reactions and draw conclusions about the effects of several variables on the rate of the reaction. Prerequisite: CHEM 1142 and CHEM 1342 both with grades of "D" or better. Corequisite: CHEM 2330 with a grade of "D" or better.

CHEM 2141. Organic Chemistry Laboratory I.

This course introduces science majors to foundational laboratory techniques used in organic chemistry and provides structured practice in experimental skills essential for upper‑division coursework. Students gain experience with laboratory safety, measurement, and the use of standard equipment while performing experiments involving separation, purification, recrystallization, melting point determination, distillation, and basic spectroscopic or analytical tools such as gas chromatography and polarimetry. The scope includes hands‑on investigation of representative organic reactions, including dehydration, substitution, and bromination. The course supports development of technical proficiency and scientific reasoning in a laboratory environment. The course is separate but complementary to CHEM 2341. Prerequisite: CHEM 1342 with a grade of "C" or better and CHEM 1142 with a grade of "D" or better. Corequisite: CHEM 2341 with a grade of "D" or better.

CHEM 2142. Organic Chemistry Laboratory II.

This course builds on foundational skills from Organic Chemistry Laboratory I and provides science majors with advanced experience in organic laboratory techniques. Students apply separation and purification methods, analyze organic compounds using IR, NMR, and UV‑Visible spectroscopy, and investigate reaction mechanisms through hands‑on experimental work. The scope includes reaction setup, product isolation, and analysis for transformations such as reduction, oxidation, Diels–Alder, nitration, polymerization, Fischer esterification, and aldol condensation, as well as the synthesis of compounds such as aspirin and methyl orange. By completing the course, students will strengthen their technical proficiency and interpretive skills in preparation for upper‑division laboratory and research experiences. The course is separate but complementary to CHEM 2342. Prerequisite: CHEM 2341 with a grade of "C" or better and CHEM 2141 with a grade of "D" or better. Corequisite: CHEM 2342 with a grade of "D" or better.

CHEM 2150. Biochemistry & Metabolism Lab.

This course is the laboratory class that complements the lecture course Biochemistry and Metabolism (CHEM 2350). This laboratory course will involve conducting experiments that investigate the physical and chemical properties of biomolecules, such as proteins, carbohydrates, lipids, and nucleic acids. Experiments will examine how biomolecules behave and respond under different conditions. By the end of this course, students will have a fundamental knowledge of how biomolecules exist and behave in real-world applications, such as food composition and nutrition. Prerequisite: [CHEM 2130 and CHEM 2330] or [CHEM 2142 and CHEM 2342] with a grade of "D" or better. Corequisite: CHEM 2350 with a grade of "D" or better.

CHEM 2330. Fundamentals of Organic Chemistry.

This course is a one-semester course which covers nomenclature, structure, and reactions of organic compounds with an introduction to bioorganic molecules. This course teaches organic chemical reactions by focusing on the transformation of functional groups and explaining reaction outcomes using reaction mechanisms. Students will be able to recognize organic functional groups, predict patterns of reactivity, and apply concepts to their field of study. Instruction combines lectures, problem-solving exercises, and discussions to reinforce conceptual understanding and practical application. The course is designed for students majoring in nutrition, wildlife biology, clinical laboratory sciences, and agriculture. Prerequisite: CHEM 1342 with a grade of "D" or better.

CHEM 2341. Organic Chemistry I.

This course is the first of two lecture courses in organic chemistry. It introduces fundamental principles of organic molecular structure, bonding, nomenclature, and reaction mechanisms. The course examines the chemistry and reactivity of major functional groups including alkanes, alkenes, alkynes, alcohols, ethers, and alkyl halides and introduces basic spectroscopic methods for characterizing organic compounds. Instruction emphasizes problem-solving, mechanism-based reasoning, and application of chemical principles through lectures, discussions, and problem sets. By the end of the course, students will be able to interpret organic reactions, predict reactivity patterns, and relate organic chemistry concepts to applications in fields such as biochemistry and materials science. Prerequisite: CHEM 1342 with a grade of “C” or better.

CHEM 2342. Organic Chemistry II.

This course is the second of two lecture courses in organic chemistry. It explores the structure, nomenclature, reactions, and mechanisms of aldehydes, ketones, carboxylic acids and carboxylic acid derivatives, aromatic compounds, conjugated systems, and amines. Students will develop a deep understanding of carbonyl reactivity, resonance, aromaticity, oxidation-reduction reactions, and strategies for the synthesis and characterization of these molecules. Instruction combines lectures, problem-solving exercises, and discussions to reinforce conceptual understanding and practical application. In this course, students will learn to interpret organic reactions, predict reactivity patterns, conduct multistep synthesis reactions, and apply concepts to fields such as biochemistry and materials science. Prerequisite: CHEM 2341 with a grade of “C” or better.

CHEM 2350. Biochemistry & Metabolism.

This course is a lecture-based course that introduces students to biochemistry and metabolism. This course is designed to teach students the importance of fundamental biomolecules including proteins, carbohydrates, lipids, and nucleic acids in the human body. Students will learn the chemical composition and biological role of these biomolecules in all aspects of the human body, including genetics and metabolic processes (metabolism). Students will learn the fundamentals of biochemistry and apply their knowledge to human health and disease. This course is complementary to the Biochemistry and Metabolism laboratory course (CHEM 2150). Prerequisite: [CHEM 2130 and CHEM 2330] or [CHEM 2142 and CHEM 2342] with grades of "D" or better.

CHEM 3190. Cooperative Education I – From Exploration to Offer.

This course prepares chemistry and biochemistry students to secure internships or co-op positions through structured career development and applied job-search training. Students engage in self-assessment and career exploration to clarify goals and identify opportunities aligned with their interests. The course guides students in developing professional materials, including tailored resumes, cover letters, and LinkedIn profiles. Through workshops and experiential activities, students practice networking, conduct informational interviews, utilize job-search platforms, and strengthen interviewing skills using the STAR method. Additional topics include offer evaluation, professional communication, and workplace readiness. By the end of the course, students will have a polished professional portfolio and a strategic plan to pursue career opportunities in their field of chemistry and biochemistry. Prerequisite: Instructor Approval.

CHEM 3210. Chemistry Pedagogy and Learning.

This course provides an introduction to pedagogical ideas relevant to the teaching and learning of chemistry and biochemistry. Students will learn key education theories and methods from STEM education research and cognitive science. Students will evaluate the processes of teaching and learning and examine structures and practices that facilitate and/or inhibit student learning. Students will engage in discussions about chemistry teaching and learning, and they will reflect on their own teaching practice in the role of Chemistry Learning Assistants. Prerequisite: Department approval.

CHEM 3245. Physical Chemistry Laboratory.

This course is designed to illustrate the core principles and methods of physical chemistry through hands-on experiments in thermodynamics, kinetics, and quantum chemistry. Throughout the term, students will apply physical models to analyze experimental data, quantitatively extracting key chemical information while utilizing rigorous statistical error analysis protocols. Beyond technical execution, the course is specifically structured to strengthen professional scientific communication skills. Through formal lab report assignments, students will learn to synthesize complex results into clear, evidence-based scholarly arguments. Prerequisites: CHEM 3330 with a grade of “C” or better and CHEM 3410 with a grade of "D" or better. Corequisites: CHEM 3340 with a grade of "D" or better.

CHEM 3276. Practical Laboratory for Biochemistry Minors.

This course introduces students with a biochemistry minor to laboratory techniques commonly used in industrial and research applications. Experiments are designed to teach students about procedures in nucleic acid research, enzyme research, and reinforce fundamental practices. Students will also perform a sequential lab series whose results will be reported in a final report. By the end of this lab series, students will be able to demonstrate knowledge and familiarity with standard biochemistry procedures and have experience translating laboratory results into technical documents. Prerequisites: CHEM 3375 or CHEM 4375 with a grade of “C” or better.

CHEM 3290. Cooperative Education II - From Practicum to Professional Growth.

This cooperative education course enables students to apply principles of chemistry and biochemistry in a professional workplace setting. Under the supervision of an industry mentor, students complete structured work assignments that involve analyzing and addressing real-world technical challenges while developing technical, organizational, and communication skills. Students receive formal performance evaluations and gain insight into professional expectations and workplace culture. To document their applied learning, students submit a technical report and/or deliver a formal presentation reflecting on their experience and contributions. Up to four hours of cooperative education may be applied toward major elective requirements. Prerequisite: Instructor approval.

CHEM 3330. Physical Chemistry I.

This course is the first of two lecture courses in physical chemistry for chemistry majors. Students will apply principles from physics and the language of mathematics to investigate topics in thermodynamics and kinetics. The major focus is on the macroscopic properties of matter, including equations of state, laws of thermodynamics and state functions, chemical and phase equilibria, kinetic molecular theory, mechanisms, and reaction dynamics. Students will solve problems and complete projects using molecular modeling software. Prerequisite: PHYS 2325 with a grade of "D" or better and CHEM 1342 and MATH 2472 both with grades of “C” or better.

CHEM 3340. Physical Chemistry II.

This course is the second of two lecture courses in physical chemistry for chemistry majors. Students will apply principles from physics and the language of mathematics to investigate topics in quantum mechanics and spectroscopy. The major focus is on the microscopic properties of matter, including principles of quantum theory, analytical model systems, atomic systems, molecular orbital theory, and spectral properties of atoms and molecules. Students will solve problems and complete projects using molecular modeling software. Prerequisite: CHEM 3330 with a grade of "C" or better. Corequisite: PHYS 2326 with a grade of “D” or better.

CHEM 3341. Descriptive Inorganic Chemistry.

This course serves as a foundational course for inorganic chemistry, covering atomic structure, bonding, and solid-state materials. An emphasis is placed on the application of periodic trends and predictions based on acid/base electron donor/acceptor interactions. Packing motifs of solid-state ionic structures are introduced, and these structures are correlated with their relative thermodynamic stabilities. The course cumulates in a representative study of the chemistry of the elements, a review of industrially significant reactions, and a survey of bioinorganic chemistry. Prerequisite: CHEM 2342 with a grade of "C" or better.

CHEM 3375. Principles of Biochemistry.

This course provides foundational undergraduate training in biochemistry through grounding in the chemical principles to understand the structure and function of nucleic acids, proteins, carbohydrates, and lipids. Emphasis is placed on understanding and predicting biomolecular behavior using core concepts from general and organic chemistry and introductory physics, applying them to enzyme mechanisms, kinetics, and biomolecular regulation. The course encourages interpretation of experimental data from common biochemical techniques, and translation between quantitative descriptions and graphical representations of data. Students construct and evaluate models of biomolecules and biological systems, read and analyze primary scientific literature, and apply structured problem-solving strategies. Corequisite: CHEM 2342 with a grade of "C" or better.

CHEM 3380. Analytical Biochemistry.

This course integrates the chemical and physical principles underlying modern biochemical techniques within the context of analyzing biological macromolecules. Emphasis is placed on applying these methods to current problems in biochemistry and molecular biology, with careful attention to experimental design and data interpretation. Students examine approaches such as spectroscopy, chromatography, electrophoresis, and molecular analysis while evaluating the various strengths and limitations of each method. The course also reinforces foundational concepts in statistics, chemistry, and physics, enabling students to critically analyze results and understand the quantitative basis of contemporary biochemical research. Prerequisite: CHEM 3375 with a grade of "C" or better.

CHEM 3381. Fundamental Biochemistry Laboratory.

This course introduces biochemistry majors to the fundamental techniques used in analytical and physical biochemistry. Students will reinforce core biochemical techniques through weekly experiments utilizing modern instrumentation. Examples of weekly experiments include the purification and characterization of proteins from native sources, enzymatic activity and kinetic assays, and separation methods through chromatography. Emphasis will be placed on experimental design, the interpretation of results, data analysis, and development of professional scientific writing skills consistent with disciplinary standards. Prerequisites: CHEM 3375 with a grade of "C" or better. Corequisite: CHEM 3380 with a grade of "C" or better.

CHEM 3390. Physical Chemistry for Biochemists.

This course examines the theories and laws of physical chemistry as they apply to biochemistry. Topics include classical thermodynamics, thermochemistry, phase equilibria, electrochemistry, chemical equilibria, chemical kinetics, statistical thermodynamics, and quantum theory. Emphasis is placed on quantitative reasoning, problem analysis, and interpretation of physical chemical principles relevant to biochemical systems. Students analyze physical chemistry problems, organize and evaluate data using logical reasoning, and develop the ability to communicate solutions clearly and accurately. The course provides a rigorous foundation for understanding molecular-level processes underlying biological phenomena and prepares students for advanced study in biochemistry, biotechnology, and related disciplines. Prerequisite: MATH 2472 with a grade of "C" or better. Corequisite: PHYS 2325 with a grade of "D" or better.

CHEM 3410. Quantitative Analysis.

This course teaches the fundamental scientific principles and methodological approaches that are used in modern analytical chemistry for the identification and quantitation of chemical substances. The topics included in this course include error analysis and propagation, statistical approaches to data evaluation, solution equilibria (acid-base, solubility, complexation), electrochemistry, and spectroscopy. Calibration methods are compared through the construction and interpretation of calibration curves that utilize the external standard, standard addition, and internal standard approaches. The laboratory component associated with this course offers a range of experiments that emphasize the accurate and precise collection of data using common analytical techniques like titrations, gravimetric analysis, and spectrophotometry. Prerequisites: CHEM 1342 with a grade of "C" or better and CHEM 1142 with a grade of "D" or better.

CHEM 4099. Predoctoral Biomedical Research Development for Undergraduates.

This course is a weekly development seminar for undergraduate students actively conducting biomedical research with Texas State faculty. The course curriculum includes training in the Responsible Conduct of Research, including but not limited to research misconduct and questionable research practices; data management; scientific rigor and reproducibility; responsible authorship and publication; peer review; conflicts of interest in research; mentor/mentee responsibilities and relationships; policies regarding laboratory safety, biosafety, and human and animal research subjects; and contemporary ethical issues in biomedical research. This course fulfills the training requirements as specified by federal agencies, including the National Institutes of Health and National Science Foundation. Prerequisite: Instructor approval.

CHEM 4231. Instrumental Analysis Laboratory.

This course introduces advanced instrumental techniques used for quantitative and qualitative analysis of inorganic and organic compounds. Experiments include electronics, ion‑selective electrode potentiometry, UV–Visible absorption spectrometry, atomic absorption spectrometry, nuclear magnetic resonance spectroscopy, infrared spectroscopy, mass spectrometry (GC–MS), gas chromatography, and high‑performance liquid chromatography. Students develop proficiency in preparing standard solutions, operating analytical instruments, collecting and analyzing data, and applying appropriate calculations. Emphasis is placed on literature search and citation, critical evaluation of results, and scientific communication through formal laboratory reports written in journal style and oral presentations. Prerequisites: CHEM 2342 and CHEM 2142 with grades of “D” or better and CHEM 3410 with a grade of "C" or better. Corequisites: CHEM 4331 with a grade of "D" or better.

CHEM 4241. Inorganic Synthesis and Chemical Analysis Laboratory.

This course is an integrated chemistry laboratory that is constructed to illustrate a variety of chemical synthesis, separation, characterization, and analysis of inorganic and organic materials. The course is designed to bolster scientific communication skills through intensive writing and presentation assessments based on laboratory experiments. Methods used in this course include vacuum and inert/Schlenk line techniques for the synthesis of air-sensitive compounds. Preparative scale purification techniques including column chromatography, crystallization, and distillation will be performed. Modern spectroscopy techniques and instrumental approaches will be applied to analyze and characterize chemical materials. Prerequisites: CHEM 4231 and CHEM 4331 with grades of "D" or better. Corequisite: CHEM 4341 with a grade of "D" or better.

CHEM 4295. Laboratory Development and Practice.

This course prepares future educators pursuing 8–12 Chemistry or 8–12 Physical Science certification to design and facilitate safe, effective, and engaging laboratory experiences. Through discussing, reflecting on, and applying pedagogical theory, future teachers learn to cultivate student engagement in both laboratory and classroom settings. The course challenges future teachers to design interactive demonstrations and adapt traditional laboratory experiments to foster critical thinking and safe, inquiry‑based of scientific concepts. Practical skills such as managing chemical storerooms, ordering supplies, ensuring proper chemical disposal, and maintaining safety in 8-12 laboratory settings are developed through hands-on projects and interactive case-based scenarios. Prerequisite: Minimum 2.5 Overall GPA.

CHEM 4299. Undergraduate Research.

This course is available to undergraduate chemistry or biochemistry majors only and provides structured faculty‑mentored research. Students explore the scope of scientific inquiry by participating in activities such as literature review, data collection, and data analysis. Emphasis is placed on hands‑on experimentation, data interpretation, and the use of appropriate instrumentation or computational tools. By completing the course, students will strengthen scientific reasoning, practice clear communication of results, and develop the research skills expected of chemistry and biochemistry graduates. The course may be repeated for credit, with a maximum of four semester hours applicable toward advanced chemistry electives. Prerequisite: Instructor approval.

CHEM 4310. Medicinal Chemistry.

This course surveys modern approaches to drug discovery and mechanisms of drug action with a primary focus on the molecular structures and properties of therapeutic agents. Students will examine the principles of pharmacokinetics, pharmacodynamics, and structure-activity relationships (SAR) as they relate to lead discovery and optimization. Methodology includes the comparative analysis of drug discovery case studies in the chemotherapy of cancer, microbial infections, and cardiovascular diseases. Through this comprehensive curriculum, students will be equipped with a foundational understanding of medicinal design and the biochemical evaluation of drugs necessary for advanced research or professional careers in the biomedical fields. Prerequisite: CHEM 3375 or CHEM 4375 with a grade of "C" or better.

CHEM 4312. Organometallic Chemistry.

This course describes organometallic chemistry — the chemistry of the metal–carbon bond. The course will focus primarily on how different combinations of transition metal and organic ligand afford different coordination geometries and reactivities in synthetic and biological organometallics. Students learn by tackling assignments and in-class problems, the latter affording them a detailed set of notes covering structure, reactions and catalysis. Overall, students will learn about research at the intersection of organic and inorganic chemistry, thereby having a holistic, uncompartmentalized understanding of molecular species. Prerequisite: CHEM 2342 and CHEM 3341 both with grades of “C” or better.

CHEM 4331. Principles of Analytical Instrumentation.

This course examines the principles and operation of modern instrumental methods used for chemical measurement and sample characterization. Optical components and designs are explored, including calculations used to assess instrument performance. Coverage includes instruments used for atomic spectroscopy, molecular spectroscopy, and mass spectrometry. Approaches to surface analysis are introduced to illustrate how chemical compositions and structures are characterized at interfaces. Electroanalytical techniques are analyzed to understand relationships between electrical signals and chemical behavior. Separation methods, including gas chromatography and high‑performance liquid chromatography, are incorporated to evaluate the mechanisms by which sample mixtures are separated and their components identified. Prerequisite: CHEM 2341 with a grade of “D” or better and CHEM 3410 with a grade of “C” or better.

CHEM 4333. Spectroscopy.

This course introduces a range of spectroscopic methods involving radiation across the electromagnetic spectrum. Students examine the physical principles and practical considerations of Mössbauer, X‑ray, ultraviolet‑visible, infrared, Raman, electron paramagnetic resonance, and nuclear magnetic resonance spectroscopies. Emphasis is placed on understanding the quantum mechanical basis of spectroscopic transitions and the types of structural and chemical information each technique provides. Students learn to select appropriate spectroscopic methods for characterizing unknown organic and inorganic materials, interpret spectroscopic data, and use these data to propose plausible chemical structures. The course develops analytical reasoning skills essential for modern chemical research and professional practice. Prerequisite: CHEM 2342 with a grade of “C” or better.

CHEM 4341. Advanced Inorganic Chemistry.

This course covers fundamental bonding concepts based on symmetry and group theory, the vibrational and electronic structure of inorganic compounds, and metal complex chemistry. Topics examined include the relationship between the electronic structure of metal complexes and their thermodynamic and kinetic properties. The course provides opportunities for students to develop proficiency in the naming and geometries of coordination complexes including organometallic complexes. In addition, ligand exchange and coupling reactions will be studied as an introduction to catalysis. With this knowledge, spectroscopic data may be correlated with the properties of metal complexes. Prerequisite: CHEM 3340 and CHEM 3341 both with grades of "D" or better.

CHEM 4350. Modern Molecular Modeling.

This course involves observing the different computational models of chemical behavior ranging from small molecules to proteins. Students will learn contemporary molecular modeling techniques and software used to model chemical and/or biochemical behavior in various physical chemical conditions. In addition, students will learn the application of molecular modeling techniques to examples of scientific applications, including but not limited to drug discovery and materials research. By the end of this course, students will be prepared to use computational models for generating scientific hypotheses for their research experiments. Prerequisite: CHEM 3340 with a grade of "D" or better.

CHEM 4351. Polymer Chemistry.

This course provides a comprehensive introduction to polymer chemistry, including polymer synthesis, characterization, and applications. Students will study key polymerization reactions, molecular weight and distribution, structure–property relationships, and fundamental techniques such as GPC, NMR, DSC, and TGA. Emphasis is placed on understanding how chemical structure influences polymer properties and material performance. The course provides a broad foundation in polymer chemistry and materials, preparing students in Chemistry, Chemical Engineering, Materials Science, or related fields for advanced study or practical applications. Prerequisite: CHEM 2342 with a grade of “C” or better.

CHEM 4360. Molecular Biology.

This course provides Biochemistry majors and minors with advanced knowledge of the field of molecular biochemistry in bacteria, archaea, and eukaryotes. The chemical mechanisms and macromolecular systems of genome organization, DNA replication, RNA transcription, and translation are discussed in the context of cell replication, DNA damage and repair, and human disease. Major themes that span these mechanisms include the regulation of gene expression at the genomic, transcriptional, translational, and post-translational level, incorporating macromolecular interactions, post-translational modification of proteins, signal transduction, and cell cycle checkpoints, as well as modern biotechnological methods that utilize and/or adapt these fundamental processes. Prerequisite: CHEM 3375 or CHEM 4375 either with a grade of "D" or better.

CHEM 4371. Directed Study.

This course provides an opportunity for students to pursue an independent study in a selected area of chemistry or biochemistry under the supervision of a faculty member. Students will examine a defined topic through guided reading, analysis of resource materials, and structured academic tasks. The specific subject area, objectives, and expected outcomes will be established in consultation with the instructor. This course supports the development of discipline‑specific knowledge, self‑directed learning skills, and the ability to engage in focused study within a specialized area of interest. Prerequisite: Instructor Approval.

CHEM 4375. Biochemistry.

This course provides a rigorous introduction to biochemistry, emphasizing the chemical environment of the cell, pH, and bioenergetic principles. The scope encompasses an in-depth analysis of structure and function of essential biomolecules – nucleic acids, proteins, lipids, and carbohydrates – with additional focus on carbohydrate metabolism, enzyme kinetics and cellular regulation. The instructional methodology utilizes traditional lecture-based delivery as well as collaborative problem-solving to reinforce conceptual understanding. Upon completion, students will demonstrate a comprehensive grasp of molecular mechanisms and regulatory processes. Corequisite: CHEM 2342 with a grade of "C" or better.

CHEM 4382. Mentored Research in Biochemistry.

This course is the second of two advanced biochemistry laboratory courses. The course focuses on reviewing current research publications, gaining experience in independent biochemical research, and becoming skilled at communicating research results in written and oral form. Various independent experiments are planned with and performed under the guidance of individual research faculty. These may involve isolation, manipulation, and characterization of biomolecules. Students will become proficient in searching the scientific literature, reading and discussing relevant scientific papers, analyzing data and organizing research results, reviewing research of peers, and preparing professional written reports and oral presentations of independent research results. Prerequisite: CHEM 4481 with a grade of "C" or better.

CHEM 4385. Metabolism.

This course provides an in-depth study of the biodegradation and biosynthesis of carbohydrates, lipids, amino acids, proteins, and nucleic acids, with a focus on human metabolism. Students build upon principles of structure/function relationships of biomolecules to carry out bioenergetic analysis of the major metabolic pathways in human metabolism. Students apply chemical and evolutionary principles to predict the effect of different metabolic states in the whole organism, and to explain the complex homeostasis necessary for living systems. Prerequisite: CHEM 3375 or CHEM 4375 with a grade of "D" or better.

CHEM 4390. Supramolecular Chemistry.

This course covers the nature of intermolecular interactions leading to molecular recognition in solution and in the solid state. Emphasis on the supramolecular features of biological systems is followed by a brief introduction to engineering molecular structures. Students will examine common biological systems such as membranes, enzymes, oxygen transport systems and replication of genetic information in terms of their supramolecular architecture and will extend these principles from nature towards explaining synthetic molecular structures. The ability to read and interpret current scientific literature relevant to the study of supramolecular chemistry is a major focus of the course. Prerequisite: CHEM 2342 with a grade of “C” or better.

CHEM 4396A. Materials Chemistry.

This course examines the principles and chemistry of the synthesis, structure, and properties of materials, including nanomaterials and inorganic, organic, and hybrid materials. Key concepts include structure and bonding in solids, material synthesis and processing, sol–gel chemistry, materials characterization methods, and the electrical, electrochemical, and optical properties of materials. The course provides an overview of solid‑state chemistry and introduces the principles and theory underlying sol–gel processes and characterization techniques. Current topics and trends in materials chemistry, as well as applications in energy, electronics, and healthcare, are examined. Students develop a foundational understanding that supports advanced coursework and research in materials chemistry. Prerequisite: CHEM 3341 with a grade of “C” or better.

CHEM 4481. Advanced Biochemistry and Molecular Biology Laboratory.

This course provides students with practical experience in the design and execution of modern molecular biology techniques. Emphasis is placed on the development of scientific writing skills and the effective presentation of laboratory data through figures and tables. Topics covered in the course include gene cloning, amplification of DNA by polymerase chain reaction (PCR), DNA purification and characterization by gel electrophoresis, purification of tagged proteins expressed in bacteria, western blotting and computer analysis of DNA and protein sequences. Prerequisites: CHEM 3381 with a grade of “C” or better and CHEM 3380 with a grade of "D" or better.

CHEM 5110. Seminar in Chemistry.

This course is designed to provide students with opportunities to engage with current researchers in chemistry and biochemistry. Over the semester, students become regular participants in the department’s seminar program, attending talks delivered by visiting scientists who are actively shaping the field. For chemistry majors, they present their own research proposal stepping into the role of speaker rather than audience. This experience allows them to practice public speaking, respond to questions and provide justification for methodological choices, and receive formative feedback. Graduate students may repeat Seminar in Chemistry twice for a total of three semester hour credits.

CHEM 5195. Professional Development of Graduate Assistants.

This course is the first part of a two-course, comprehensive professional training for Graduate Teaching Assistants (GTAs) and Graduate Instructional Assistants (GIAs). The curriculum is designed to equip participants with the foundational knowledge and practical skills required for effective instruction, classroom management, and compliance with institutional and federal guidelines. Core components of the course include advanced pedagogy, active learning methodologies, mentoring strategies, and professional communication. Participants will receive in-depth instruction on laboratory safety, including accident prevention, hazardous material management, chemical hygiene protocols, and emergency preparedness.

CHEM 5199B. Thesis.

This course provides continued enrollment for graduates engaged in thesis research and writing in chemistry or biochemistry. Work is conducted under the direct supervision of a thesis advisor and involves activities necessary for completing the thesis, such as data collection, analysis, preparation of written dissertation chapters, and oral defense of the thesis. Candidates may participate in laboratory research, computational studies, or other approved investigative approaches as appropriate to their study. Enrollment may be needed for each long semester while conducting research or writing to maintain steady progress until the thesis is submitted for binding.

CHEM 5285. Laboratory Development Practice.

This course prepares future educators pursuing 8–12 Chemistry or 8–12 Physical Science certification to design and facilitate safe, effective, and engaging laboratory experiences. Through discussing, reflecting on, and applying pedagogical theory, future teachers learn to cultivate student engagement in both laboratory and classroom settings. The course challenges future teachers to design interactive demonstrations and adapt traditional laboratory experiments to foster critical thinking and safe, inquiry‑based learning of scientific concepts. Practical skills such as managing chemical storerooms, ordering supplies, ensuring proper chemical disposal, and maintaining safety in 8–12 laboratory settings are developed through hands‑on projects and interactive case‑based scenarios.

CHEM 5295. Professional Development of Graduate Assistants.

This course is the second part of a two-course, comprehensive professional training for Graduate Teaching Assistants (GTAs) and Graduate Instructional Assistants (GIAs). The course modules will introduce policies and responsibilities associated with instructional roles, including FERPA, and Title IX, the Texas State University Honor Code, and procedures for addressing academic and behavioral concerns. Topics covered will include comprehensive training in the Responsible Conduct of Research (RCR), emphasizing data integrity, plagiarism prevention, and ethical decision-making within academic and research environments.

CHEM 5299B. Thesis.

This course provides continued enrollment for graduates engaged in thesis research and writing in chemistry or biochemistry. Work is conducted under the direct supervision of a thesis advisor and involves activities necessary for completing the thesis, such as data collection, analysis, preparation of written dissertation chapters, and oral defense of the thesis. Candidates may participate in laboratory research, computational studies, or other approved investigative approaches as appropriate to their study. Enrollment may be needed for each long semester while conducting research or writing to maintain steady progress until the thesis is submitted for binding.

CHEM 5310. Medicinal Chemistry.

This course surveys modern approaches to drug discovery and mechanisms of drug action with a primary focus on the molecular structures and properties of therapeutic agents. Students will examine the principles of pharmacokinetics, pharmacodynamics, and structure-activity relationships (SAR) as they relate to lead discovery and optimization. Methodology includes the comparative analysis of drug discovery case studies in the chemotherapy of cancer, microbial infections, and cardiovascular diseases. Through this comprehensive curriculum, students will be equipped with a foundational understanding of medicinal design and the biochemical evaluation of drugs necessary for advanced research or professional careers in the biomedical fields.

CHEM 5311. Natural Products, Anti-Infective, and Anti-Cancer Agents.

This course surveys the major classes of secondary metabolites, focusing on their classification, nomenclature, biosynthesis, and structural elucidation. Students examine the chemical principles governing the utilization of natural products as primary leads in the development of modern antimicrobial and anticancer agents. Methodology includes the analysis of metabolic pathways and the application of advanced organic and biochemical techniques to the chemistry‑biology interface. Through this curriculum, students will be equipped with the analytical expertise required for sophisticated research in natural product‑based drug discovery and the evaluation of naturally derived bioactive molecules within the pharmaceutical and biotechnological industries.

CHEM 5312. Organometallic Chemistry.

This course describes organometallic chemistry — the chemistry of the metal–carbon bond. The course will focus primarily on how different combinations of transition metal and organic ligand afford different coordination geometries and reactivities in synthetic and biological organometallics. Students learn by tackling assignments and in-class problems, the latter affording them a detailed set of notes covering structure, reactions and catalysis. Overall, students will learn about research at the intersection of organic and inorganic chemistry, thereby having a holistic, uncompartmentalized understanding of molecular species.

CHEM 5313. Principles and Applications of Mass Spectrometry.

This course describes the physical principles underpinning mass spectrometers – from ion sources to analyzers and detectors – and how these enable a broad range of measurements. The different instrument architectures will be introduced in terms of electromagnetism and the paths analytes take, and evaluated in terms of their strengths, weaknesses and what samples are applicable. Students will participate in a series of lectures and hands-on experiments and become familiar with the theory and practical aspects of mass spectrometry.

CHEM 5320. Computational Chemistry.

This course involves observing the different computational models of chemical behavior ranging from small molecules to proteins. Students will learn contemporary molecular modeling techniques and software used to model chemical and/or biochemical behavior in various physical chemical conditions. In addition, students will learn the application of molecular modeling techniques to examples of scientific applications, including but not limited to drug discovery and materials research. By the end of this course, students will be prepared to use computational models for generating scientific hypotheses for their research experiments. This course is the graduate level for CHEM 4350 and has additional objectives that challenge graduate students to generate molecular models at an advanced level.

CHEM 5321. Advanced Organic Chemistry.

This course examines advanced organic chemistry through the lens of reaction mechanisms rather than the traditional classification by functional groups. Students explore the fundamental pathways underlying reactions of structurally disparate compounds, including polar reactions under acidic and basic conditions, pericyclic processes, and free-radical chemistry. Methodology centers on an active-learning, non-lecture format where students develop proficiency in applying curved-arrow notation to propose mechanistic pathways through guided board-work and collaborative participation. Through this structured approach, students will develop a deep mechanistic intuition and the analytical proficiency required to predict and justify complex chemical transformations in advanced research environments.

CHEM 5330. Physical Chemistry.

This course explores the fundamental principles of physical chemistry and their applications across various chemical disciplines. Key topics include thermodynamics, kinetics, and atomic structure. Students will examine both theoretical foundations and the practical application of physical chemistry models to experimental data. A central emphasis is placed on leveraging scientific programming to analyze and interpret experimental datasets. Through interactive demonstrations and problem sets, students will bridge the gap between theory and experiment, gaining hands-on experience using computational tools to numerically solve complex chemical problems.

CHEM 5333. Spectroscopy.

This course introduces a range of spectroscopic methods involving radiation across the electromagnetic spectrum. Through interactive lectures, written and oral assignments, and in‑class and homework problems, students examine the physical principles and practical considerations of Mössbauer, X‑ray, ultraviolet‑visible, infrared, Raman, electron paramagnetic resonance, and nuclear magnetic resonance spectroscopies. Emphasis is placed on understanding how each technique probes molecular structure and dynamics. By the end of the course, students will be able to select appropriate spectroscopic methods to characterize unknown organic or inorganic materials, interpret resulting data, and use spectroscopic evidence to propose plausible chemical structures.

CHEM 5341. Advanced Inorganic Chemistry.

This course covers fundamental bonding concepts based on symmetry and group theory, the vibrational and electronic structure of inorganic compounds, and metal complex chemistry. Topics examined include the relationship between the electronic structure of metal complexes and their thermodynamic and kinetic properties. The course provides opportunities for students to develop proficiency in the naming and geometries of coordination complexes, including organometallic complexes. In addition, ligand exchange and coupling reactions will be studied as an introduction to catalysis. With this knowledge, spectroscopic data may be correlated with the properties of metal complexes.

CHEM 5342. Bioinorganic Chemistry.

This course describes natural and artificial metalloproteins ― from secondary structures to atomistic views of how cofactors catalyze reactions and transport species. Complementing lectures, students will also use contemporary protein visualization tools and research the primary literature and structural repositories. Topics covered in the course include dioxygen transport and activation, electron-transfer, dinitrogen and hydrogen activation, photosystem and oxygen evolution, zinc-containing proteins, carbon dioxide reduction, and modern advancements in the field of bioinorganic chemistry. Overall, students will develop foundational knowledge in metalloenzyme structure, function, and reaction mechanisms.

CHEM 5351. Polymer Chemistry.

This course provides a comprehensive introduction to polymer chemistry, including polymer synthesis, characterization, and applications. Students study key polymerization reactions, molecular weight and distribution, structure–property relationships, and fundamental analytical techniques such as gel permeation chromatography, nuclear magnetic resonance spectroscopy, differential scanning calorimetry, and thermogravimetric analysis. Emphasis is placed on understanding how chemical structure influences polymer properties and material performance. Graduate‑level engagement includes exposure to controlled polymerizations, functional polymers, and emerging applications. The course develops a foundational and practical understanding of polymer science relevant to modern chemical and materials research.

CHEM 5353. Polymer Properties and Characterization.

This course examines how the structure of polymeric (soft) materials—described by molecular weight, chemical makeup, and morphology—controls their thermal, mechanical, and rheological behavior. Students will learn methods for defining and measuring molecular weight and its limitations, along with thermal analysis techniques such as differential scanning calorimetry and thermogravimetric analysis. Nuclear magnetic resonance, infrared spectroscopy, and microscopy will be used to relate molecular and supramolecular structure to material properties. Mechanical and flow behaviors, including tensile strength, viscosity, and viscoelasticity, will be discussed in the specific context of polymers as soft materials, distinguishing them from other classes of materials. Prerequisite: CHEM 5351 with a grade of "C" or better.

CHEM 5355. Physical Chemistry of Polymers.

This course is an advanced examination of how polymer molecular structure determines bulk properties and behavior. It covers polymer thermodynamics, chain conformation, solution behavior, and phase transitions, then connects these ideas to viscoelasticity and flow in melts and solutions through polymer chain dynamics. Polymer morphology is treated via crystallization, glass transition, and self-organization in bulk materials. The course also develops Flory-Huggins Theory to explain polymer miscibility, phase separation, and solvent–polymer interactions from a thermodynamic perspective.

CHEM 5365. Separation Methods in Chemistry.

This course describes the separation of chemical mixtures, an important process in isolating fine and commodity chemicals alike. Students will learn principles of size-exclusion chromatography, gel electrophoresis, gas chromatography, liquid chromatography and mass spectrometry. Although primarily a lecture course, students will also learn by working on assignments, homework/in-class problems and an experiment. On completing this course, students will have a strong understanding of the intermolecular interactions that govern molecular separations of organics, inorganics and polymers, and be able to identify complex structures from tandem mass spectrometric data.

CHEM 5366. Quantitative Methods in Biophysical Chemistry.

This course integrates the physical, chemical, and biological aspects of fundamental biophysical methods, including spectroscopy, calorimetry, and hydrodynamics. These methods are compared in the context of both classical and contemporary research problems. Students develop quantitative skills in multiple analytical approaches used to characterize biological systems across a range of scales and levels of complexity. Emphasis is placed on understanding how physical and chemical principles govern biomolecular behavior and measurement. The course provides the foundational quantitative framework necessary to study biological macromolecules using modern biophysical techniques.

CHEM 5370. Problems in Chemistry.

This course is designed to be flexibly tailored to a particular contemporary topic of interest within the broad scope of chemistry, biochemistry, biophysics, or materials chemistry. Using that topic as a unifying theme, students develop skills in critical analysis of primary literature, quantitative reasoning, and molecular-level interpretation of complex systems. This course emphasizes independent inquiry, facilitating students to explore and critically evaluate modern experimental and computational approaches, and integrate concepts across disciplines to address a well-defined scientific problem. This course is open to graduate students on an individual basis by arrangement with a particular faculty member. May be repeated once with different emphasis for additional credit. Prerequisite: Instructor Approval.

CHEM 5375. Biochemistry.

This course provides a rigorous introduction to biochemistry, emphasizing the chemical environment of the cell, pH, and bioenergetic principles. The scope encompasses an in-depth analysis of structure and function of essential biomolecules – nucleic acids, proteins, lipids, and carbohydrates – with additional focus on carbohydrate metabolism, enzyme kinetics and cellular regulation. The instructional methodology utilizes traditional lecture-based delivery as well as collaborative problem-solving to reinforce conceptual understanding. Upon completion, students will demonstrate a comprehensive grasp of molecular mechanisms and regulatory processes.

CHEM 5381. Physical Biochemistry.

This course is an introduction to the physical techniques of biochemistry with emphasis on the interpretation of experimental data obtained from electrophoresis, chromatography, immunological methods, ultracentrifugation, spectroscopy, calorimetry, and emerging techniques. Experimental data will be incorporated into the course as much as possible to show practical use and demonstrate techniques for analyzing results. Students completing the course will be able to understand many of the techniques and methods that are presented in biochemistry-based journal articles and at scientific seminars. Grades for each student will be determined by using assigned homework problem sets and in-class exams.

CHEM 5382. Enzymology.

This course examines the chemical and physical principles governing enzyme function in biological systems. Topics include enzyme structure–function relationships, active-site architecture, and the forces driving molecular recognition and catalysis. Students analyze chemical and kinetic mechanisms using thermodynamic, spectroscopic, and kinetic frameworks, with attention to experimental and computational approaches. The course also explores the roles of enzymes in metabolic pathways and cellular regulation, emphasizing integration of molecular detail with physiological context through literature analysis, problem-solving, and case-based study.

CHEM 5383. Molecular Biology & Molecular Genetics.

This course gives students an understanding of the related fields of molecular biology and molecular genetics. Strong emphasis is placed on molecular biology techniques, including DNA cloning and gene expression, DNA libraries, DNA sequencing, PCR methods, Southern, Northern, and Western blotting, microarrays, chromatin immunoprecipitation, and CRISPR technologies. Topics are presented in the context of how molecular approaches are used to generate new scientific knowledge. Contemporary applications of molecular methods in areas such as human genetic disease research, forensic analysis, and medical and archaeological testing are examined. Students engage with course material through lectures and analysis of primary molecular biology research articles.

CHEM 5384. Current Topics in Biochemistry and Molecular Biology.

This course provides graduate students with advanced knowledge in areas related to the biochemistry and molecular biology of cancer. Topics discussed during the first half of the semester include emerging technologies like CRISPR, gene therapy, and the processes of DNA replication, DNA repair, recombination, signal transduction, and cell cycle checkpoints. Later in the semester, characteristics of cancer cells and environmental/genetic factors that have been linked to their formation are addressed. New approaches to cancer treatment are discussed. The course includes student presentations and analysis of journal articles related to carcinogenesis. Prerequisites: CHEM 5381 with a grade of "C" or better.

CHEM 5385. Metabolism.

This course provides an in-depth study of the biodegradation and biosynthesis of carbohydrates, lipids, amino acids, proteins, and nucleic acids, with a focus on human metabolism. Students build upon principles of structure/function relationships of biomolecules to carry out bioenergetic analysis of the major metabolic pathways in human metabolism. Students apply chemical and evolutionary principles to predict the effect of different metabolic states in the whole organism, and to explain the complex homeostasis necessary for living systems. This course may be stacked with an undergraduate section of CHEM 4385.

CHEM 5386. Proteins.

This course covers advanced biochemistry topics related to proteins, including protein structure, conformational dynamics, structure–function relationships, ligand binding and catalysis, post‑translational modification and regulation, and protein–protein interactions within cellular mechanisms and signaling pathways. Foundational and advanced concepts from chemistry, biology, and physics are integrated and applied to classic and contemporary problems in protein biochemistry through the lenses of chemical biology, biophysics, and cell biology. Current methodologies for examining protein sequence, structure, dynamics, and function are discussed in the context of both seminal and contemporary primary literature.

CHEM 5387. Nucleic Acid Chemistry.

This course covers advanced biochemistry topics related to nucleic acids. Topics include nucleic acid structure and properties, catalytic nucleic acids, protein–nucleic acid interactions, higher‑order protein–nucleic acid complexes, nucleic acid therapeutics, and current methodologies for analyzing and manipulating nucleic acids. Contemporary findings from the primary scientific literature are integrated throughout the course. Instruction uses a variety of formats, including lectures, student presentations, and guided discussions. By the end of the course, students develop advanced conceptual understanding of nucleic acid chemistry and apply this knowledge to generate scientifically grounded hypotheses addressing specific biochemical questions. Prerequisite: CHEM 5383 with a grade of "C" or better.

CHEM 5390. Supramolecular Chemistry.

This course covers the nature of intermolecular interactions leading to molecular recognition in solution and in the solid state. Emphasis on the supramolecular features of biological systems is followed by a brief introduction to engineering molecular structures. Students will examine common biological systems such as membranes, enzymes, oxygen transport systems and replication of genetic information in terms of their supramolecular architecture and will extend these principles from nature towards explaining synthetic molecular structures. The ability to read, interpret, and critique current scientific literature relevant to the study of supramolecular chemistry is a major focus of the course. This course may be stacked with an undergraduate section of CHEM 4390.

CHEM 5391. Chemical Biology.

This course introduces the emerging field of chemical biology and the tools used in contemporary research to analyze and manipulate biological processes with small molecules. Students develop a foundation in the design and synthesis of chemical probes to interrogate biological systems of varying complexity. Emphasis is placed on implementing and interpreting chemical and biochemical assays using examples drawn from current primary literature. Topics are presented within the broader context of small‑molecule discovery and development for applications in biological research and human health. Instruction integrates lectures, literature analysis, and discussion to connect chemical principles with biological function.

CHEM 5395. Fundamentals of Research.

This course is an introduction to the rules, ethics, and professional practices of scientific research. Students completing the course will meet federal obligations for training in the responsible conduct of research (RCR) and will participate in discussions that focus on the practice of science with integrity, accuracy, efficiency, and objectivity. Students will explore career development and opportunities in chemistry and biochemistry by learning about different career pathways and identifying resources for professional growth. Students will learn how to navigate the MS degree programs in Chemistry and Biochemistry, including where to find resources, support, and information about program requirements and policies.

CHEM 5396A. Materials Chemistry.

This course examines principles of the chemistry of the synthesis, structure, and properties of materials, including nanomaterials, and inorganic, organic and hybrid materials. Key concepts covered in the course include structure and bonding in solids, material synthesis and processing, sol-gel chemistry, materials characterization methods, and electrical, electrochemical and optical properties of materials. Current topics and trends in materials chemistry and applications of materials in energy, electronics, and healthcare will be covered. Students will be equipped with a foundation for advanced coursework and/or research in the field of materials chemistry.

CHEM 5399A. Thesis.

This course represents a student’s initial thesis enrollment for graduates engaged in thesis research and writing in chemistry or biochemistry. Work is conducted under the direct supervision of a thesis advisor and involves activities necessary for completing the thesis, such as data collection, analysis, and preparation of written dissertation chapters. Candidates may participate in laboratory research, computational studies, or other approved investigative approaches as appropriate to their study. No thesis credit is awarded until the thesis is completed.

CHEM 5399B. Thesis.

This course provides continued enrollment for graduates engaged in thesis research and writing in chemistry or biochemistry. Work is conducted under the direct supervision of a thesis advisor and involves activities necessary for completing the thesis, such as data collection, analysis, preparation of written dissertation chapters, and oral defense of the thesis. Candidates may participate in laboratory research, computational studies, or other approved investigative approaches as appropriate to their study. Enrollment may be needed for each long semester while conducting research or writing to maintain steady progress until the thesis is submitted for binding.

CHEM 5599B. Thesis.

This course provides continued enrollment for graduates engaged in thesis research and writing in chemistry or biochemistry. Work is conducted under the direct supervision of a thesis advisor and involves activities necessary for completing the thesis, such as data collection, analysis, preparation of written dissertation chapters, and oral defense of the thesis. Candidates may participate in laboratory research, computational studies, or other approved investigative approaches as appropriate to their study. Enrollment may be needed for each long semester while conducting research or writing to maintain steady progress until the thesis is submitted for binding.

CHEM 5999B. Thesis.

This course provides continued enrollment for graduates engaged in thesis research and writing in chemistry or biochemistry. Work is conducted under the direct supervision of a thesis advisor and involves activities necessary for completing the thesis, such as data collection, analysis, preparation of written dissertation chapters, and oral defense of the thesis. Candidates may participate in laboratory research, computational studies, or other approved investigative approaches as appropriate to their study. Enrollment may be needed for each long semester while conducting research or writing to maintain steady progress until the thesis is submitted for binding.

CHEM 7101. Doctoral Assistant Development.

This course examines the roles, responsibilities, and professional practices associated with serving as a doctoral teaching assistant. Students analyze instructional support activities, classroom management practices, and communication strategies relevant to undergraduate and graduate learning environments. Topics may include instructional preparation, grading and assessment procedures, academic integrity, inclusive classroom practices, and effective interaction with faculty and students. The course evaluates institutional policies, ethical considerations, and professional standards governing instructional support roles. Emphasis is placed on developing procedural knowledge and practical skills necessary to support course delivery while maintaining academic and professional expectations.

CHEM 7110. Advances in Molecular and Biophysical Chemistry.

This course supports the professional development of doctoral students in the Integrated Molecular and Biophysical Chemistry PhD program by fostering independent engagement with emerging scientific knowledge. Students examine current advances within and beyond their dissertation areas through seminar attendance, presentations on recent literature, and presentations of ongoing graduate research. The course develops skills essential for doctoral success, including primary literature searching, critical evaluation of scientific findings, and professional oral communication. Emphasis is placed on independent thinking, interdisciplinary awareness, and the ability to contextualize new discoveries within the broader molecular and biophysical chemistry landscape.

CHEM 7199. Dissertation.

This course provides enrollment for doctoral candidates engaged in dissertation research and writing in integrated molecular and biophysical chemistry. Work is conducted under the direct supervision of a dissertation advisor and involves activities necessary for completing the dissertation, such as research planning, data collection, analysis, and preparation of written dissertation chapters. Candidates may engage in laboratory research, computational studies, or other approved investigative approaches as appropriate to their study. Enrollment is required for each long semester while conducting research or writing to maintain steady progress towards completion of the doctoral degree.

CHEM 7200. Graduate Research.

This course provides pre-candidacy doctoral students with an elective research option to conduct original scientific research in integrated molecular and biophysical chemistry, carried out under direct supervision of their dissertation committee chair. Students examine relevant experimental methodologies and laboratory techniques, evaluate strategies for generating reliable preliminary data, and evaluate approaches used in defining feasible research objectives. This course also guides students in reviewing disciplinary literature, organizing emerging research questions, and understanding the procedural steps involved in constructing a dissertation proposal. Through these activities, students strengthen their capacity to plan and execute early-stage research. In these ways, the course enables students to prepare effectively for their doctoral candidacy examination.

CHEM 7201. Graduate Laboratory Rotations.

This course coordinates three structured short research opportunities for students to inform their selection of a doctoral committee chair and doctoral dissertation research group. Since students work in several laboratories during their first semester in the Integrated Molecular and Biophysical Chemistry program, they experience a variety of research opportunities, techniques, methodologies, and mentoring styles. The course includes structured self-assessment mechanisms and constructive feedback from supervising faculty, enabling both students and faculty to make an informed decision about initiating a productive dissertation research project and an intensive mentoring relationship.

CHEM 7299. Dissertation.

This course provides enrollment for doctoral candidates engaged in dissertation research and writing in integrated molecular and biophysical chemistry. Work is conducted under the direct supervision of a dissertation advisor and involves activities necessary for completing the dissertation, such as research planning, data collection, analysis, and preparation of written dissertation chapters. Candidates may engage in laboratory research, computational studies, or other approved investigative approaches as appropriate to their study. Enrollment is required for each long semester while conducting research or writing to maintain steady progress towards completion of the doctoral degree.

CHEM 7300. Graduate Research.

This course provides pre‑candidacy doctoral students with an elective research option to conduct original scientific research in integrated molecular and biophysical chemistry, carried out under direct supervision of their dissertation committee chair. Students examine relevant experimental methodologies and laboratory techniques, evaluate strategies for generating reliable preliminary data, and assess approaches used in defining feasible research objectives. The course also guides students in reviewing disciplinary literature, organizing emerging research questions, and understanding the procedural steps involved in constructing a dissertation proposal. Through these activities, students strengthen their capacity to plan and execute early‑stage research. In these ways, the course enables students to prepare effectively for their doctoral candidacy examination.

CHEM 7305A. Physico-Chemical Properties and Metabolism of Xenobiotics.

This course introduces students to the physico‑chemical properties of small molecules and examines how these properties influence their use as chemical probes in biological systems. Emphasis is placed on the role of metabolic processes in limiting, activating, or modifying xenobiotics and on the use of chemical probes to investigate these processes. Students explore experimental and computational methods for determining relevant physico‑chemical and metabolic properties of biologically active compounds. The course integrates concepts from chemistry, physics, and biology to support molecular‑level analysis of xenobiotic behavior in complex biological environments.

CHEM 7311. Natural Products, Anti-Infective, and Anti-Cancer Agents.

This course surveys the major classes of secondary metabolites, focusing on their classification, nomenclature, biosynthesis, and structural elucidation. Students examine the chemical principles governing the utilization of natural products as primary leads in the development of modern antimicrobial and anticancer agents. Methodology includes the analysis of metabolic pathways and the application of advanced organic and biochemical techniques to the chemistry-biology interface. Through this curriculum, students will be equipped with the analytical expertise required for sophisticated research in natural product-based drug discovery and the evaluation of naturally derived bioactive molecules within the pharmaceutical and biotechnological industries.

CHEM 7330. Environmental Chemistry.

This course examines environmental chemistry principles relevant to natural and engineered systems. It covers principles of geochemistry and atmospheric chemistry to understand pollutant sources, transport, transformation, and impacts across the atmosphere, hydrosphere, lithosphere, and biosphere, with integration of sustainability concepts and green chemistry and engineering approaches. Students engage in quantitative analysis, modeling, and evaluation of treatment and remediation processes. By the end of the course, students are expected to assess contaminant behavior and design or evaluate environmentally responsible solutions using sustainability-based and green engineering frameworks.

CHEM 7342. Bioinorganic Chemistry.

This course describes natural and artificial metalloproteins ― from secondary structures to atomistic views of how cofactors catalyze reactions and transport species. Complementing lectures, students will also use contemporary protein visualization tools and research the primary literature and structural repositories. Topics covered in the course include dioxygen transport and activation, electron-transfer, dinitrogen and hydrogen activation, photosystem and oxygen evolution, zinc-containing proteins, carbon dioxide reduction, and modern advancements in the field of bioinorganic chemistry. Overall, students will develop foundational knowledge in metalloenzyme structure, function, and reaction mechanisms.

CHEM 7354. Eukaryotic Molecular Biology and Macromolecular Structure.

This course examines the regulation of gene expression in eukaryotes through an approach that emphasizes macromolecular and atomic‑level structure. Topics include eukaryotic DNA replication, DNA repair, recombination, transcription, RNA processing, translation, and post‑translational protein modification. The course also introduces macromolecular structure determination methods and their application to studying gene expression pathways and regulatory mechanisms. Students develop a conceptual understanding of eukaryotic molecular biology and acquire skills needed to analyze contemporary literature, generate research hypotheses, and design experiments appropriate for advanced research and grant proposal development.

CHEM 7361. Quantitative Methods in Biophysical Chemistry.

This course will integrate the physical, chemical, and biological aspects of fundamental biophysical methods, including spectroscopy, calorimetry, and hydrodynamics. These methods are compared in the context of both classical and contemporary problems. Students develop a functional quantitative skillset in multiple analytical methods used to characterize biological systems across a range of scales and levels of complexity. This course provides students with the physical and chemical foundation needed to quantitatively study biological macromolecules using modern biophysical approaches.

CHEM 7385. Metabolism and Metabolomics.

This course will cover the metabolism of biomacromolecules and the principles and practice of metabolomics in contemporary biological chemistry and molecular biochemistry research. It will cover (1) biosynthesis and biodegradation of carbohydrates, lipids, amino acids, proteins, and nucleic acids; (2) fundamental physical, chemical, and biological principles of metabolomics; and (3) applications of metabolomics in biomedicine and medicinal chemistry. Students will utilize information about metabolic pathways along with analysis of experimental metabolomics results to consider the impact of metabolic dysregulation on human health. Students will develop skills in critical reading and analysis of both classical and contemporary literature in metabolomics.

CHEM 7391. Chemical Biology.

This course introduces the emerging field of chemical biology and the tools used in contemporary research to analyze and manipulate biological processes with small molecules. Students develop a foundation in the design and synthesis of chemical tools to interrogate biological systems of varying complexity. Emphasis is placed on the implementation and interpretation of chemical and biochemical assays using these tools, with examples drawn from current primary literature. Topics are presented within the broader context of small‑molecule discovery and development for applications in biological research and human health.

CHEM 7395. Fundamentals in Molecular and Biophysical Chemistry.

This course provides doctoral level students with an integrated overview of physics, chemistry, and biology concepts central to molecular and biophysical chemistry. Students apply core principles from biochemistry, organic chemistry, and biophysics, including chemical synthesis, thermodynamics, and molecular modeling, to molecular problems in complex biological systems. Emphasis is placed on quantitative reasoning and critical evaluation of primary literature. Through lectures, problem sets, and interactive discussion, students develop a shared scientific vocabulary across disciplines and a broad scientific foundation. The course prepares students to pursue interdisciplinary research projects and to collaborate effectively across subdisciplines throughout their doctoral studies.

CHEM 7399. Dissertation.

This course provides enrollment for doctoral candidates engaged in dissertation research and writing in integrated molecular and biophysical chemistry. Work is conducted under the direct supervision of a dissertation advisor and involves activities necessary for completing the dissertation, such as research planning, data collection, analysis, and preparation of written dissertation chapters. Candidates may engage in laboratory research, computational studies, or other approved investigative approaches as appropriate to their study. Enrollment is required for each long semester while conducting research or writing to maintain steady progress toward completion of the doctoral degree.

CHEM 7599. Dissertation.

This course provides enrollment for doctoral candidates engaged in dissertation research and writing in integrated molecular and biophysical chemistry. Work is conducted under the direct supervision of a dissertation advisor and involves activities necessary for completing the dissertation, such as research planning, data collection, analysis, and preparation of written dissertation chapters. Candidates may engage in laboratory research, computational studies, or other approved investigative approaches as appropriate to their study. Enrollment is required for each long semester while conducting research or writing to maintain steady progress toward completion of the doctoral degree.

CHEM 7699. Dissertation.

This course provides enrollment for doctoral candidates engaged in dissertation research and writing in integrated molecular and biophysical chemistry. Work is conducted under the direct supervision of a dissertation advisor and involves activities necessary for completing the dissertation, such as research planning, data collection, analysis, and preparation of written dissertation chapters. Candidates may engage in laboratory research, computational studies, or other approved investigative approaches as appropriate to their study. Enrollment is required for each long semester while conducting research or writing to maintain steady progress toward completion of the doctoral degree.

CHEM 7999. Dissertation.

This course provides enrollment for doctoral candidates engaged in dissertation research and writing in integrated molecular and biophysical chemistry. Work is conducted under the direct supervision of a dissertation advisor and involves activities necessary for completing the dissertation, such as research planning, data collection, analysis, and preparation of written dissertation chapters. Candidates may engage in laboratory research, computational studies, or other approved investigative approaches as appropriate to their study. Enrollment is required for each long semester while conducting research or writing to maintain steady progress toward completion of the doctoral degree.